A review of the occurrence of non-alkaloid constituents in Uncaria species and their structure-activity relationships
نویسندگان
چکیده
A good understanding of a medicinal plant is based on fundamental knowledge of its chemical constituents and their pharmacological effects. The non-alkaloids constituents isolated from Uncaria species have been increasingly investigated recently. The anti-inflammatory, anti-oxidant and anti-cancer properties have been studied in many non-alkaloids constituents isolated from Uncaria species. This paper emphasizes the phytochemical and chemotaxonomic analyses of non-alkaloid constituents isolated from fifteen Uncaria species. Their structural activity-relationships have also been discussed.
منابع مشابه
Selective COX-2 Inhibitors: A Review of Their Structure-Activity Relationships
Non-steroidal anti-inflammatory drugs (NSAIDs) are the competitive inhibitors of cyclooxygenase (COX), the enzyme which mediates the bioconversion of arachidonic acid to inflammatory prostaglandins (PGs). Their use is associated with the side effects such as gastrointestinal and renal toxicity. The therapeutic anti-inflammatory action of NSAIDs is produced by the inhibition of COX-2, while the ...
متن کاملSelective COX-2 Inhibitors: A Review of Their Structure-Activity Relationships
Non-steroidal anti-inflammatory drugs (NSAIDs) are the competitive inhibitors of cyclooxygenase (COX), the enzyme which mediates the bioconversion of arachidonic acid to inflammatory prostaglandins (PGs). Their use is associated with the side effects such as gastrointestinal and renal toxicity. The therapeutic anti-inflammatory action of NSAIDs is produced by the inhibition of COX-2, while the ...
متن کاملA Systematic Review on Main Chemical Constituents of Papaver bracteatum
Papaver bracteatum Lindly (Papaveraceae) is an endemic species of Iran which has economic importance in drug industries. The main alkaloid of the plant is thebaine which is used as a precursor of the semi-synthetic and synthetic compounds including codeine and naloxone, respectively. This systematic review focuses on main component of Papaver bracteatum and methods used to determine thebaine. ...
متن کاملAnti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content.
Cat's claw is an herbal medicine from the Amazon that is used widely to treat inflammatory disorders. The purpose of this study was to characterize the antioxidative and antiinflammatory properties of cat's claw, Uncaria tomentosa (UT) and Uncaria guianensis (UG). Alkaloids and flavanols were determined using reversed-phase HPLC; scavenging of 1,1-diphenyl-2-picrilhydrazyl (DPPH), hydroxyl radi...
متن کاملAnticonvulsive Effect of Seed Extract of Caesalpinia bonducella (Roxb.)
In traditional system of Indian medicine, C.bonducella is widely used for its antipyretic, antiperiodic, anticonvulsive, and antiparalytic activities. For assessing anticonvulsant activity, pentylenetetrazole, maximal electro shock, strychnine- and picrotoxin-induced convulsions models were used. Diazepam was used as a standard reference for all models except maximal electro shock model, wh...
متن کامل